Sensitivity of Propionibacterium acnes towards Commercial Anti-Acne Formulations
Chandan Shivamallu
Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India.
Safa Sharif
Department of Microbiology, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India.
Gayatri Vidya
Department of Studies in Food Technology, Davangere University, Davangere, 577007, India.
Chandan Dharmashekar
Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India.
Bhargav Shreevatsa
Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru-570015, India.
Kollur Shiva Prasad
Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka 570 026, India.
Bramhadev Pattnaik
Institute of Veterinary Science and Animal Husbandry, SoA University, Odisha, India & Former Director, ICAR-DFMD, Mukteswar, Nainital, India and FAO Ref Centre for FMD in South Asia, Bhubaneswar, Odisha, India.
Sharanagouda S. Patil
ICAR-DFMD and FAO Ref Centre for FMD in South Asia, Mukteswar, Nanital, 26318, UK.
Chandrashekar Srinivas
ICAR, National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru 560064, India.
S. M. Gopinath
Department of Studies in Biotechnology, Davangere University, Davangere-577007, Karnataka, India.
P. Ashwini *
Department of Microbiology, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India.
*Author to whom correspondence should be addressed.
Abstract
Propionibacterium acnes are aerotolerant anaerobic, gram-positive bacilli that form part of normal flora. They produce several pro-inflammatory substances that can trigger an immune response in the host by an influx of inflammatory leukocytes into the strands, causing inflammatory lesions that leave behind scars. Repeated isolation of Propionibacterium acnes may reduce efficacy among the resistant types, clearly explaining Acne lesions' importance. The Counter acne therapies are often the first treatment choice due to the convenience of cost and time over clinical appointments. However, not all of the commercially available anti-acne formulations are supported by clinical studies. The present study was conducted to test the efficacy of selected commercial anti-acne gel formulations. The microscopic observation and biochemical studies conform to the presence of anti-acne activity. A sensitivity test was performed on all the isolates of Propionibacterium acnes by well diffusion technique. The selected over-the-counter anti-acne gel formulations failed to produce any inhibition zone.
Keywords: Acne vulgaris, propionibacterium, facial acne lesions, sensitivity test