Particular Patterns of the Influence of the Physiology of Normal Pregnancy on the Pharmacokinetics of Drugs in the Liver

Eliza Umarovna Khasueva

Stavropol State Medical University, Stavropol, Russia.

Yana Evgenevna Efimova

Stavropol State Medical University, Stavropol, Russia.

Diana Khasanbievna Khatanova

Children's Polyclinic No. 1, Lyubertsy, Moscow region, Russia.

Leila Ibragimovna Bachieva

Stavropol State Medical University, Stavropol, Russia.

Alina Yurievna Maslova *

Socmedica, Skolkovo, Russia.

Kamila Nurmagomedovna Magomedova

Dagestan State Medical University, Makhachkala, Dagestan Republic, Russia.

Aiza Gazimagomedovna Galbatsova

Dagestan State Medical University, Makhachkala, Dagestan Republic, Russia.

Miyasat Sirazhutdinovna Kurbanova

Dagestan State Medical University, Makhachkala, Dagestan Republic, Russia.

Taibat Yunadievna Mirzaeva

Dagestan State Medical University, Makhachkala, Dagestan Republic, Russia.

Ahmed Romanovich Zadaev

Chechen State University, Grozny, Chechen Republic, Russia.

*Author to whom correspondence should be addressed.


Abstract

Pregnant women are the most "untouchable" group of people in relation to pharmacological research due to ethical and legal aspects, as well as concerns for the health and integrity of the fetus. And that is why pregnant women practically do not participate in clinical, pharmacodynamic, or pharmacokinetic testing. The mechanisms of teratogenesis are unpredictable, and in this case mutations can occur regardless of the duration of pregnancy and at any level. In women during pregnancy, the activity of liver enzyme systems involved in drug metabolism changes completely, which affects their clearance. This should be taken into account when selecting drugs and dosages for the treatment of various diseases. Our study showed that during pregnancy, a significant decrease in the intrinsic hepatic clearance of the CYP1A2 substrate is enhanced by a decrease in the binding of theophylline to plasma proteins and an increase in the glomerular filtration rate.

Keywords: liver enzymes, pregnancy, caffeine, proguanil, lamotrigine, phenytoin, methadone


How to Cite

Khasueva, E. U., Efimova, Y. E., Khatanova, D. K., Bachieva, L. I., Maslova, A. Y., Magomedova, K. N., Galbatsova, A. G., Kurbanova, M. S., Mirzaeva, T. Y. and Zadaev, A. R. (2021) “Particular Patterns of the Influence of the Physiology of Normal Pregnancy on the Pharmacokinetics of Drugs in the Liver”, Journal of Pharmaceutical Research International, 33(55A), pp. 256–261. doi: 10.9734/jpri/2021/v33i55A33830.