Anti-inflammatory Activity of Herbal Tablet of Phyllanthus emblica on Carrageenan-induced Paw Edema in Wistar Rats
Amulyaratna Behera *
School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India.
Himansu Bhusan Samal
School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India.
Dinesh Kumar Sharma
School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India.
Satish Kanhar
School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India.
Atul Kadam
Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, Ghogaon, Maharashtra, India.
Prachi Khamkar
Department of Pharmaceutics, University of Mumbai, Mumbai, Maharashtra, India.
Suchismeeta Behera
Postgraduate Department of Zoology, Utkal University, Bhubaneswar, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: In the current investigation, tablet dosage form of hydroalcohol extract of leaves of P. emblica was developed and evaluated foranti-inflammatory activities.
Methodology: Hydroalcohol extract of leaves of P. Emblica (HPE) was prepared and formulated tablet dosage form. The mechanical properties e.g. hardness, friability, disintegration, and dissolution of tablet were evaluated. Anti-inflammatory activities of HPE (150 mg/kg) and HPE (650 mg) tablets were performed in carrageenan induced hind paw edema in wistar rats.
Results: The anti-inflammatory activity was found to be significant in carrageenan inducedpaw edema. HPE (150 mg/kg) and HPE tablets (650 mg) were significantly (p < 0.05) reduced the carrageenan induced paw edemaby 66.41% and 69.43% respectively as compared to carragenan control. The % inhibition of standard drug (dichlorofenac sodium) was recorded to be 70.18% after 5 h.
Conclusion: The study standardised the development of HPE tablet and its anti-inflammatory effect.
Keywords: Phyllanthus emblica, dissolution, stability, carrageenan induced, anti-inflammatory activity