Granisetron Versus Ondansetron for Prevention of Post-operative Nausea and Vomiting (PONV) in Patients Undergoing Laparoscopic Cholecystectomy
Muhammad Naeem
Department of Anesthesiology, SICU & Pain Center, Peoples University of Medical and Health Sciences For Women, Pakistan.
Rafia Tabassum
Department of Anesthesiology, SICU & Pain Center, Peoples University of Medical and Health Sciences For Women, Pakistan.
Muhammad Saleh Khaskheli
Department of Anesthesiology, SICU & Pain Center, Peoples University of Medical and Health Sciences For Women, Pakistan.
Aijaz Hussain Awan
Department of Anesthesiology, SICU & Pain Center, Peoples University of Medical and Health Sciences For Women, Pakistan.
Munazzah Meraj
Department of Biochemistry, IPRS, Peoples University of Medical and Health Sciences For Women, Pakistan.
Rao Irfan *
Institute of Pharmaceutical sciences, Peoples University of Medical and Health Sciences for Women, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Aim: To determine the efficacy of single dose Granisetron versus ondansetron in preventing PONV in patients undergoing elective laparoscopic cholecystectomy.
Methodology: A total of 100 patients were included in this study after the ethical approval of PUMHSW. Patients were randomly divided into two groups, in (Group G) 50 patients were given Granisetron and in (group O) 50 patients were given Ondansetron. Every patient was evaluated for PONV at one hour, two hours, three hours, six hours, twelve hours and 24 hours post operatively.
Results: A sample of 100 patients with age between 20-60 years (mean age 43.72±5.67 years), were included in this study. Patients were received granisetron 1 mg I/V and other patients received ondansetron 4mg I/V before induction.
Conclusion: we concluded that there was no significant difference between efficacy of granisetron and ondansetron as the p-value is found to be ≤0.05.
Keywords: Efficacy, postoperative nausea and vomiting, PONV, granisetron, ondansetron, laparoscopic cholecystectomy