Association of Genetic Polymorphism of Tumor Necrosis Factor-α in the Development of Coronary Heart Disease in Elderly Patients
Bekkhan Saidmagomedovich Mezhidov *
Saratov State Medical University named after V.I.Razumovsky, Saratov, Russia.
Khava Idrisovna Bekova
Ingush State University, Magas, Republic of Ingushetia, Russia.
Aishat Alikovna Edieva
North Ossetia State Medical Academy, Vladikavkaz, Republic of North Ossetia, Russia.
Khava Ismailovna Madalova
North Ossetia State Medical Academy, Vladikavkaz, Republic of North Ossetia, Russia.
Victoria Alekseevna Malakhova
Stavropol State Medical University, Stavropol, Russia.
Zama Arbievna Uspaeva
Rostov State Medical University, Rostov-on-Don, Russia.
Markha Sharipovna Tachaeva
Rostov State Medical University, Rostov-on-Don, Russia.
Amina Magomedovna Tsinaeva
Rostov State Medical University, Rostov-on-Don, Russia.
Alina Yurievna Maslova
Socmedica, Skolkovo, Russia.
Shamil Vakhaevich Khodisov
Chechen State University, Grozny, Chechen Republic, Russia.
*Author to whom correspondence should be addressed.
Abstract
The research project outlines a new look at the concept of "inflammaging" and the role of the subclinical inflammatory process in various age-associated pathology, in particular coronary heart disease. Particular attention is paid to the tumor necrosis factor-α -cytokine, which plays an important role in the pathogenesis of chronic inflammatory processes and in the aging process. The increased content of tumor necrosis factor-α leads to the emergence and accumulation of various diseases, disability and mortality of elderly and senile people.
Tumor necrosis factor-α influences various risk factors for cardiovascular pathology. This substance aggravates various breakdowns in metabolism, primarily causing insulin resistance. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (osteoporosis) and sarcopenia. Currently available data prove the important role of tumor necrosis factor-α in various age-associated pathologies.
Keywords: Cytokines, tumor necrosis factor-α (TNF-α), atherosclerosis, aging, senile age, comorbid patients, longevity, coronary heart disease