Preparation and in-vitro Evaluation of Ranitidine Mucoadhesive Microspheres for Prolonged Gastric Retention

K. Vijayabhaskar

Faculty of Pharmaceutical Sciences, Oil Technological Research Institute, Jawaharlal Nehru Technological University, Anantapur, Ananthapurmau-515001, Andhra Pradesh, India.

Kambham Venkateswarlu *

Faculty of Pharmaceutical Sciences, Oil Technological Research Institute, Jawaharlal Nehru Technological University, Anantapur, Ananthapurmau-515001, Andhra Pradesh, India.

S. B. Thirumalesh Naik

Faculty of Pharmaceutical Sciences, Oil Technological Research Institute, Jawaharlal Nehru Technological University, Anantapur, Ananthapurmau-515001, Andhra Pradesh, India.

R. Kiran Jyothi

Faculty of Pharmaceutical Sciences, Oil Technological Research Institute, Jawaharlal Nehru Technological University, Anantapur, Ananthapurmau-515001, Andhra Pradesh, India.

G. Nethra Vani

Faculty of Pharmaceutical Sciences, Oil Technological Research Institute, Jawaharlal Nehru Technological University, Anantapur, Ananthapurmau-515001, Andhra Pradesh, India.

K. B. Chandrasekhar

Faculty of Pharmaceutical Sciences, Oil Technological Research Institute, Jawaharlal Nehru Technological University, Anantapur, Ananthapurmau-515001, Andhra Pradesh, India.

*Author to whom correspondence should be addressed.


Abstract

Aim: The purpose of this study was to prepare and characterize mucoadhesive microspheres of Ranitidine (RNT) for prolonged gastric retention.

Materials and Methods: Mucoadhesive microspheres were prepared by ionic gelation method using the polymer Sodium alginate (SA) along with various copolymers like Sodium Carboxy Methyl Cellulose (SCMC), Hydroxy Propyl Methyl Cellulose K100 (HPMC K100), Carbopol 934P (Car 934P), Eudargit RS100 (Eud RS100) and characterized by the parameters like particle size, micromeritic properties, drug entrapment efficiency, swelling index, mucoadhesion capacity and in-vitro drug release.

Results: FTIR studies confirmed that there was no chemical interaction between the drug and polymers. The flow properties were found to be excellent and in-vitro drug release study was performed in pH 1.2 HCl buffer for 24 h time duration. From the in-vitro release studies, formulations F1, F5 and F8 showed optimum drug release, thereby optimized for further study.

Conclusion: Kinetic studies proved that the drug release from the microspheres followed zero order kinetics and mechanism was found to be diffusion, particularly non-fickian or anomalous transport. Relatively formulation F1 showed better results than the F5 & F8 formulations.

Keywords: Car 934P, HPMC K100, Ionic gelation method, mucoadhesive microspheres, ranitidine


How to Cite

Vijayabhaskar, K., Venkateswarlu, K., Naik, S. B. T., Jyothi, R. K., Vani, G. N. and Chandrasekhar, K. B. (2016) “Preparation and in-vitro Evaluation of Ranitidine Mucoadhesive Microspheres for Prolonged Gastric Retention”, Journal of Pharmaceutical Research International, 10(2), pp. 1–12. doi: 10.9734/BJPR/2016/22670.