A Rare Case of Renal Squamous Cell Carcinoma with Underlying Staghorn Calculus as Confounding Factor

Shubham Pratap Durge

Department of General Surgery, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.

Anurag Anupkumar Bhattacharjee *

Department of General Surgery, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.

Harshal Ramteke

Department of General Surgery, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.

Abhishek Gupta

Department of General Surgery, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.

Varun Kulkarni

Department of General Surgery, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.

Shyamal Shaha

Department of General Surgery, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.

Roshani Mannek

Department of General Surgery, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.

*Author to whom correspondence should be addressed.


Abstract

Renal cell carcinoma is one of the most common kidney pathologies in adults, responsible for approximately 90-95% of cases. The most common variant is clear cell accounting for 60-70% of cases, while papillary accounts for 10-15% of the cases.

Diagnosis of carcinoma in the presence of staghorn calculus is seen in less than 1% of patients in recorded data. However, squamous cell carcinoma of the kidney is a rare condition usually associated with chronic irritation by a foreign body, most likely due to staghorn calculus. Here we present a case report of a 65 year old male who came with complaint of pain in the abdomen since two months associated with malaise, weight loss and fever.

CT KUB was suggestive of a non-excreting enlarged left kidney with multiple calculi with abnormal cortical and periureteric lesions with encasement of adjacent vessels. Histopathological report revealed a rare case of primary squamous cell carcinoma, most probably originating from the pelvis and secondarily infiltrating the renal parenchyma and associated with nephrolithiasis and hydronephrosis. Initially the patient was managed conservatively. Later the patient underwent nephrectomy.

Keywords: Squamous cell carcinoma, nephrolithiasis, hydronephrosis, abdominal pain, pyelonephritis


How to Cite

Durge, S. P., Bhattacharjee, A. A., Ramteke, H., Gupta, A., Kulkarni, V., Shaha, S. and Mannek, R. (2021) “A Rare Case of Renal Squamous Cell Carcinoma with Underlying Staghorn Calculus as Confounding Factor”, Journal of Pharmaceutical Research International, 33(53A), pp. 1–7. doi: 10.9734/jpri/2021/v33i53A33633.