The Role of Hyperhomocysteinemia in the Pathogenesis of Thromboocclusive Diseases
Ibragim Abdulganievich Yusupov
Rostov State Medical University, Rostov-on-Don, Russia.
Mubarik Dziyaudinovna Akaeva
Tyumen State Medical University, Tyumen, Russia.
Natalia Yurievna Stepanova
Tyumen State Medical University, Tyumen, Russia.
Nikita Vladimirovich Slysarenko
Rostov State Medical University, Rostov-on-Don, Russia.
Omar Ruslanovich Gaidarbekov *
Chechen State University, Grozny, Chechen Republic, Russia.
Eldar Abdurahmanovich Saidov
Rostov State Medical University, Rostov-on-Don, Russia.
KhavraAdamovna Dudugova
Chechen State University, Grozny, Chechen Republic, Russia.
Zaytun Said-Magomedovna Dikieva
Chechen State University, Grozny, Chechen Republic, Russia.
Alina Yuryevna Maslova
Socmedica, Skolkovo, Russia.
*Author to whom correspondence should be addressed.
Abstract
Homocysteine is a sulfur-containing non-proteinogenic amino acid that is an intermediate product of methionine metabolism. With excessive accumulation of homocysteine in the body, a state of hyperhomocysteinemia occurs, which has attracted the attention of doctors since the middle of the last century and received a serious impetus for research after the publication of data on the role of hyperhomocysteinemia in the pathogenesis of thromboocclusive diseases. To date, there are more than 7.5 thousand scientific papers devoted to the study of hyperhomocysteinemia, monothematic international conferences on clinical and therapeutic aspects of hypermonocysteinemia are held every year. In the Russian Federation, a detailed study of the role of homocysteine and its side effects in excess is of particular interest due to the prevalence of cardiovascular pathologies (according to statistics of the Ministry of Health of Russia-49.27% of deaths of Russians fall on this cohort of diseases). This is an important fact in Russian medicine, which deserves close attention from researchers and scientists.
Keywords: Hyperhomocysteinemia, homocysteine, hypertension, cardiovascular disease, arterial hypertension, CBS gene