Evaluation of the Antigenotoxic Potential of Methanolic Leaves Extract of Triticum aestivum in Mice
Gaurav Jain *
IES Institute of Pharmacy, IES University Campus, Kalkheda, Ratibad Main Road, Bhopal, 462044, Madhya Pradesh, India.
Shailesh M. Kewatker
Rajarshi Shahu College of Pharmacy, Buldana, 443001, Maharashtra, India.
Govind Nayak
Lakshmi Narain College of Pharmacy, Kalchuri Nagar, Raisen Road, Bhopal, 462022, Madhya Pradesh, India.
Amit Nayak
GD Goenka University, Sohna-Gurgaon Road, Sohna Gurgon, 122103, India.
*Author to whom correspondence should be addressed.
Abstract
Mutations are changes to the nucleotide sequence of the genetic material of an organism. Reactive oxygen species (ROS) play an important role in process like mutagenesis, carcinogenesis and aging by their ability to damage cellular DNA. Inhibition of mutagenesis or carcinogenesis is generally not based on one specific mechanism. Protection against cancer can occur at different stages of the complicated processes of carcinogenesis. Naturally occurring antioxidants have been extensively studied for their capacity to protect organisms and cells from oxidation. Triticum aestivum (T. aestivum) have revealed its medicinal potential for some human diseases; therefore, this study aimed to evaluate the genotoxic and antigenotoxic potential of methanolic extract. To accomplish this, the methanolic extract of T. aestivum was evaluated for its antigenotoxic effect using the chromosomal aberrations and micronucleus assay of bone marrow cells of mice.T. aestivum extract has shown significant protection against Cyclophosphamide induced micronucleus formation and chromosomal aberrations.
Keywords: Triticum aestivum, cyclophosphamide, chromosomal aberrations, micronucleus assay, antigenotoxic, genotoxicity, carcinogenesis