An Observational Prospective Study on Prevalence and Monitoring of Adverse Drug Reactions in Tertiary Care Teaching Hospital
Sneha Gangisetty *
Department Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Lam Guntur-522034, India.
Sowmya Nadendla
Department Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Lam Guntur-522034, India.
Prem kumar Goka
Department Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Lam Guntur-522034, India.
Zahedabano .
Department of Pharmacology, Guntur Medical College, Guntur, India.
N. Lakshmi Prasanthi
Department of Pharmacology, Guntur Medical College, Guntur, India.
Nallani Venkata Rama Rao
Department Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Lam Guntur-522034, India.
Rama Rao Nadendla
Department Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Lam Guntur-522034, India.
*Author to whom correspondence should be addressed.
Abstract
Objective: To study the prevalence of ADRs in the in-patient departments of General Medicine, Pediatrics, Dermatology at tertiary care hospital.
Materials and Methods: An Observational Prospective Study was designed from February to July 2015 in which Prevalence of ADR was calculated. A total of 107 ADR’s were observed from 1334 patients. ADR’s were evaluated for causality by WHO-UMC Scale, Naranjo’s scale, Severity by Hartwig & Siegel scale, Preventability by Schumock & Thornton and classification by Rawling & Thompson criteria.
Results: Prevalence of ADR’s was found to be 8.02% and male to female ratio was 0.81. ADR’s mostly occurred in the age group 31-40 (27.10%). Skin was found to be the most commonly affected organ system (24.29%) among which rashes and urticaria were the most common type of ADR’S reported, majority of the adverse drug reactions were due to Antimicrobials (22.42%). For Casuality of ADR’s according to Naranjo Scale 26.16% of adverse drug reactions were assessed to be probable, using WHO-UMC scale 33.64% were considered as probable. Similarly Severity assessment shows majority of the reactions as moderate (53.27%).
Conclusion: By early detection of adverse drug reactions, necessary action can be taken to prevent mortality & morbidity from such reactions.
Keywords: Adverse drug reactions, WHO-UMC, Nariño scale, drugs, pharmacovigilance, causality, adverse events.