In Silico Drug Discovery of 4-Hyroxypanduratin A, 6-Gingerol and Luteolin Targeting Nipah Virus
Anurag Verma *
Department of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
Piyush Mittal
Department of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
Milind S. Pande
Department of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
Neelanchal Trivedi
Department of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Nipah Virus is a zoo tonic virus and has re-emerged again with more deadliness. NiV has infected many animals and humans worldwide and a huge loss to life has been faced. NiV contains a Fusion protein on its outer membrane which helps in the virus entry into the host cell. This fusion protein is a virulent factor and is a major anti-viral target. Many medicinal plants have been used against viral diseases, current research aims towards the potential of three daily dietary food elements that can be used as an anti-viral agent. In-silico studies are performed with 4-hyroxypanduratin A, 6-gingerol and Luteolin against the NiV-F and binding energies were calculated. It was reported that these phyto-compounds have good negative binding energies and they have the promising potential against Nipah Virus. Further in-vitro research can be performed with these phyto-compounds to design a specific drug against Nipah Virus.
Keywords: Human life, 4-hyroxypanduratin A, 6-gingerol, AutoDock, Luteolin, Nipah Virus, health care