Reproductive Organ Activities of Morinda lucida Ethanol Root Extract on Male and Female Albino Rats Tramadol HCL Induced Infertility
Nkiruka Millicent Amadi
Department of Medical Laboratory Science, ESUT College of Medicine, Enugu State University of Science and Technology, Enugu State, Nigeria.
Peter Uwadiegwu Achukwu
Department of Medical Laboratory Science, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
Nonyelum V. Anoh
Department of Medical Laboratory Science, ESUT College of Medicine, Enugu State University of Science and Technology, Enugu State, Nigeria.
Emmanuel Ifeanyi Obeagu
*
Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria.
Ngozika O. Achukwu
Department of Medical Microbiology, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
Ogechukwu Florence Odo
Department of Medical Laboratory Science, ESUT College of Medicine, Enugu State University of Science and Technology, Enugu State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Infertility is a serious issue disturbing reproductive ages in all society now and calling for solution for continuity. Infertility were induced on groups of animals with separate sexes; M, M1, M2 and M3; F, F1, F2 andF3 with daily subcutaneous administration of 20 mg/kg body weight tramadol HCl for 42 days before respective ethanol root extract administrations of (500, 1000, 1500) mg/ kg body weight for 10 days. The animals were anaesthetized and sacrificed; uterus, ovaries, testes, epididymis were dissected out for histomorphological studies. There is evidence of dose treatment of infertility among treated groups. From the organ weight study, both the male and the female organ weight in the groups remained significantly unchanged. There are dose dependent treatments with the male and female tramadol treatment. The result is more pronounced in the increased dose of ethanol root extract (1000 mg/kg and 1500 mg/ kg) body weight treated testicular cells. This study indicated that Morinda lucida has a prophylactic effect against tramadol-induced testicular damage.
Keywords: Reproductive organ activities, Morinda lucida, ethanol root extract, male and female albino rats, tramadol HCL induced infertility