An Insight into 4-Thiazolidinones
Smriti Sahu *
ITS College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh-201206, India and Institute of Pharmaceutical Research, Gla University, Mathura, Uttar Pradesh-281406, India.
Prabhat Kumar Upadhyay
Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh-281406, India.
Pradeep Mishra
Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh-281406, India.
*Author to whom correspondence should be addressed.
Abstract
Aims: This assessment is all about to get imminent into 4-thiazolidinones and comprehensively reviewing this molecule. 4-Thiazolidinones are known for their wide-ranging biological activities. 4 - Thiazolidinones contains thiazolidine ring having carbonyl group in the 4-position. The chemistry of thiazolidinones has drawn scientific interest through the years because this particular ring system is the core structure in a variety of synthetic compounds with a broad spectrum of biological activities such as anti-bacterial, anti-fungal, insecticidal, anti-epileptic, anti-mycobacterial, anti- inflammatory, anti-parasitic, hypnotic and anti-cancer. Structural modifications on the 4-thiazolidinone moiety, either by replacing the aryl group with the heteroaryl scaffold or by incorporating different groups and moieties (A&B) on –CH– group of nucleus paving a new pathway for the future research. It necessitates to widely reviewing the structure, chemistry and pharmacological aspects of 4-thiazolidinones.
Keywords: Aldehydes, antibiotic, anti microbial agents, drug resistance, isomerism, Schiff bases, spectroscopy, spectrum analysis, 4- thiazolidinone