Convalescent Plasma Therapy in COVID 19 an Indian Scenario: Comprehensive Review
Shruti Vimal
*
Department of Pathology, Symbiosis Medical College for Women, Symbiosis (Deemed) International University, Lavale Pune 412115, Maharashtra, India.
Pratiksha Naval
Department of Pathology, Symbiosis Medical College for Women, Symbiosis (Deemed) International University, Lavale Pune 412115, Maharashtra, India.
Manoj Sawadker
Department of Pathology, Symbiosis Medical College for Women, Symbiosis (Deemed) International University, Lavale Pune 412115, Maharashtra, India.
Pallavi Bhomia
Department of Pathology, Symbiosis Medical College for Women, Symbiosis (Deemed) International University, Lavale Pune 412115, Maharashtra, India.
Neha Jadhav
Department of Pathology, Symbiosis Medical College for Women, Symbiosis (Deemed) International University, Lavale Pune 412115, Maharashtra, India.
Shraddha Yadav
Department of Pharmacology, Symbiosis Medical College for Women, Symbiosis (Deemed) International University, Lavale, Pune 412115, Maharashtra, India.
Madhura Bhosale
Department of Pharmacology, Symbiosis Medical College for Women, Symbiosis (Deemed) International University, Lavale, Pune 412115, Maharashtra, India.
Arpana Dharwadker
Department of Pathology, D Y Patil Medical College and Research Centre, DPU, Pimpri, Pune 411027, India.
Vidya Viswanathan
Department of Pathology, D Y Patil Medical College and Research Centre, DPU, Pimpri, Pune 411027, India.
*Author to whom correspondence should be addressed.
Abstract
The recent pandemic due to Corona virus more popularly known as COVID 19 has reassessed the usefulness of historic convalescent plasma transfusion. (CPT) The CPT is one of the promising therapies in the current pandemic situation. This review was conducted to evaluate the effectiveness of CPT therapy in COVID 19 patients based on the publications reported till date. PubMed, EMBASE and Medline databases were screened up to 30 April 2021. All the records were screened as per the protocol eligibility criteria.
The main features of the studies reviewed were, convalescent plasma can reduce mortality in severely ill patients, an increase in neutralizing antibodies titre and disappearance of SARS CoV 2 RNA was observed in all the patients on CPT therapy and over all a beneficial effect on clinical symptoms after administration of CP.
Based on the review findings and the limited scientific data, CPT therapy in COVID 19 patients appear safe, clinically effective and reduces mortality. However, the need of a multicentre clinical trials, unequivocal proof of efficacy, effectiveness and the need for the standardisation of the CPT needs to be addressed immediately for the full utilisation of potential of CPT.
Keywords: Convalescent plasma therapy, COVID 19, Neutralizing Antibodies, SARS COV 2, anti SARS CoV 2 antibodies, donor selection, Passive immunization