Review for Analytical Methods for the Determination of Mefenamic Acid
T. V. Ashira
Department of Pharmaceutical Analysis, National College of pharmacy, Manassery, Kozhikode-673602, Kerala, India.
T. Mohamed Rafeeque
Department of Pharmaceutical Analysis, National College of pharmacy, Manassery, Kozhikode-673602, Kerala, India.
Saba Maanvizhi
Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Nagar, Porur, Chennai-600116, Tamilnadu, India.
S. Kathirvel *
Department of Pharmaceutical Analysis, National College of pharmacy, Manassery, Kozhikode-673602, Kerala, India.
P. C. Indukala
Department of Pharmaceutical Analysis, National College of pharmacy, Manassery, Kozhikode-673602, Kerala, India.
S. Safeetha
Department of Pharmaceutics, National College of Pharmacy, Manassery, Kozhikode, 673602, Kerala, India.
*Author to whom correspondence should be addressed.
Abstract
Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. The present review article includes a compilation of articles on the various properties along with an extensive literature survey on the reported analytical methods of MFA. Using a comprehensive computer assisted literature review; this article discusses the analytical methodologies for quantifying MFA both in active pharmaceutical ingredient and pharmaceutical dosage forms. This is the first review article in this series with focus on the analytical profile of MFA. Although, several methods like High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), spectrophotometry, fluorimetry, turbidimetry, Atomic Absorption Spectroscopy (AAS), Mass Spectroscopy (MS) and electro analytical methods were reported in the literature, HPLC stands out first for the quantification of MFA.
Keywords: Mefenamic acid, analytical methods, high performance liquid chromatography, spectroscopy, fluorimetry