Gastro-Retentive as Most Promising Drug Delivery System
Lankalapalli Srinivas
GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.
Sagar Shanti
*
GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
The aim of any research work is to find the complications associated with the drug or formulation and find the conclusion of what can be the best possible way to solve them. It has been observed that drugs with short half-life, pH-dependent solubility and having absorption window in upper part of GIT forms good drug candidate for gastro retentive system. Since the formulation reside at a particular site and releases the drug in a controlled manner. In this review article, we have focussed on a thorough understanding on the gastric region, which helped in selecting drugs, various types of gastro retentive systems, new outcomes from recent literature, and important evaluation parameters to attain formulation objective and various marketed products available.
Keywords: Stomach, gastric residence time, bioavailability, absorption window