Journal of Pharmaceutical Research International

Mortality rate caused by dengue in tropical urban life by a vector mosquito possess severe effects including children. This is an observational study carried out in a tertiary care hospital in Navi Mumbai, from June 2006 to August 2008 area which is endemic for vector borne diseases. The clinical signs, symptoms, hematological parameters and serological correlation in 100 serologically positive for IgM and IgG children confirmed by Mac ELISA were studied. Chi-square test of significance was applied between the selected laboratory and clinical parameters. The outcomes of the study were provided with a high incidence of infection was seen in the age group of 6-10 years (50%), with a male (63%) predominance affection. Fever (100%), along with Vomiting (89%), myalgia (45%) and abdominal pain (27%) are the most common symptoms associated with dengue. Other symptoms found in childrens affected by dengue shows hemorrhagic manifestation (25%), hepatomegaly (78%), as cites and effusion (50%), hem concentration (31%), leucopenia (38%), and raised serum transaminases (67%). These findings were correlated with the severity of the infection and the parameters which were statistically significant were hemorrhagic manifestation, plasma leakage with as cites and effusion, hepatomegaly, hem concentration and leucopenia. The findings would be useful in early detection and prompt management and referral of cases for preventing mortality rate in children.