Recent Advances in Nanoparticle Drug Delivery for Targeting Lymph Node -An Overview in Cancer Immunotherapy
A. A. Podutwar
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
S. A. Polshettiwar
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
A. R. Gawade *
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
Akshay Baheti
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
Manish S. Wani
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
Mayuri Ghanekar
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
Asmita Gupta
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
Purva Chondorkar
School of Pharmacy Dr.Vishwanth Karad MIT World Peace University, Survey No.124, Kothrud, Pune, Maharashtra 411038, India.
*Author to whom correspondence should be addressed.
Abstract
Generally, it is said that the lymph node plays very important role in the cancer immunotherapy. So, delivering immunomodulating compounds to lymph node can be useful strategy for cancer immunotherapy. In case of this lymph node drug delivery system, lipid nanoparticles are widely used. High amount of drugs, nucleic acids and various other compounds can easily load in lipid nanoparticle, and they are easy to be manufacture on industrial scale also. In this review, we have focused on the potential of lipid nanoparticle technology to aim lymph nodes. However, there are many factors that control the delivery of drugs to lymphatics. Before the lymphatic detection, lipid nanoformulations are necessary to go through interstitial hindrance which alters delivery of them. So, the distribution and detection of lipid nanoformulations by means of lymphatic system depend on charge present on nanoparticles, hydrophobicity, particle size and molecular weight, form & type of lipid and emulsifier concentrations are as well significant factors disturbing the delivery of drugs in the lymphatic system.
Keywords: Cancer immunotherapy, lipid nanoparticle, Lymph node, Lymphatic system, Nanocarriers