The Role of Mitochondrial Energetics and Inflammasome NLRP3 in Diabetic Cardiomyopathy
Maha Almas
Centre for Applied Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore-53700, Pakistan.
Usaal Tahir
Centre for Applied Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore-53700, Pakistan.
Mariam Zameer
Institute of Molecular biology and Biotechnology, University of Lahore 1KM Defense road, Lahore, Pakistan.
Maham Mazhar
Institute of Molecular biology and Biotechnology, University of Lahore 1KM Defense road, Lahore, Pakistan.
Qurban Ali *
Institute of Molecular biology and Biotechnology, University of Lahore 1KM Defense road, Lahore, Pakistan.
Ayesha Rafique
Institute of Molecular biology and Biotechnology, University of Lahore 1KM Defense road, Lahore, Pakistan.
Khushbukhat Khan
Atta-ur-Rehman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Sector H-12, Islamabad 44000, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Diabetic Cardiomyopathy is the worldwide leading cause of lethal heart disorders burdening the healthcare systems. Mitochondrion is the key regulator of myocardial metabolism. It fuels the cardiocytes and regulates the pumping activity of heart. People living with diabetes have defected myocardial metabolism which may likely to cause ventricular dysfunction or other heart disorders due to mitochondrial DNA (mtDNA) mutation. Furthermore, the inflammatory injury due to inflammasome activation is a potent contributor to the cardiac injuries. Though the mechanism of inflammation is still poorly known. This review highlights the association of altered mitochondrial energetics and inflammasome activation with cardiomyopathies.
Keywords: Diabetic cardiomyopathy, inflammasome, mitochondrial energetics, caspases-1, interleukin IL-1β, interleukin IL-18