Formulation and Evaluationation of Anti-Alzheimer Drug MEM HCL Nanogel
Subhasri Mohapatra *
Dr. A. P. J. Abdul Kalam University, Indore, Madhya Pradesh, India.
Sourabh Jain
College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore, Madhya Pradesh, India.
Karunakar Shukla
College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore, Madhya Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
The object of present study was to formulate and evaluate MEM HCl loaded thermo sensitive in situ nanogel for 08 nasal delivery formulations. In present project a novel drug delivery system i.e. in situ polymeric gel was designed in the manner that the gel load MEM HCl in better concentration and it also incorporates penetration enhancer as a way to enhance the absorption of release drug from gel to the systemic circulation. In this research work Different Nanoparticles were (NP) prepared, using ionotropic gelation method with slight medication in which chitosan (0.4% w/v) was dissolved in aqueous acetic acid solutions (1 % v/v) (pH 6.1), while TPP (0.1% w/v) was dissolved in deionized water. Dried nanoparticles are incorporated with in situ gel. In situ gel was prepared by cold method using the solutions of Poloxamer-188 and Carbopol-934. From this study, it is concluded that, among all formulations prepared, NG8 was the best optimized formulation. Prepared gel can be used as promising nasal drug delivery system for the anti-Alzheimer drug MEM HCl, which enhance nasal residence time owing to increased viscosity and mucoadhesive characteristics; furthermore, it also exhibited a permeation enhancing effect.
Keywords: Ionotropic gelation method, chitosan based nasal drug delivery system, in situ gel system evaluation, in-situ polymeric gel formulation