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Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice

  •  Sama Mohammed Attiyah
  •  Hoda Elsayed Mohammed

Journal of Pharmaceutical Research International, Volume 33, Issue 39A, Page 9-16
DOI: 10.9734/jpri/2021/v33i39A32134
Published: 28 July 2021

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Abstract


Background: Anti-Inflammatory properties of turmeric and extra virgin olive oil have numerous health benefits. They exert and promote anti-inflammatory actions, moreover, each gives benefits that go beyond reducing inflammation.


Objective: The aim of our study is to evaluate and compare the immunomodulatory effect of each turmeric and extra virgin olive oil (EVOO) alone or in combination.


Methods: We demonstrated the serum level of pro-inflammatory cytokines IL-6 and IL-10 in healthy male Swiss albino mice (C57BL/6 strain) after oral intake of curcumin and extra virgin olive oil for six weeks by ELISA assay. 


Results: Our results showed that dietary intake of turmeric and EVOO had a reducing effect on serum IL-6 level and could increase the production of IL-10 level significantly. Inflammatory responses of turmeric and EVOO combination appear to be more effective on health by inhibition of IL 6 and induce IL 10 production. 


Conclusion: Anti-inflammatory effect of turmeric and EVOO can play an important role in modulating the level of IL 6 and IL-10. Moreover, co-administration of them having a greater anti-inflammatory effect. 


Keywords:
  • Turmeric
  • extra-virgin olive oil
  • pro-inflammatory
  • anti-inflammatory
  • IL-6
  • IL-10
  • cytokines
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How to Cite

Attiyah, S. M. and Mohammed, H. E. (2021) “Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice”, Journal of Pharmaceutical Research International, 33(39A), pp. 9-16. doi: 10.9734/jpri/2021/v33i39A32134.
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