Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice

Sama Mohammed Attiyah

Biology Department, Faculty of Sciences and Arts, Al Kamel Branch, University of Jeddah, Jeddah, Saudi Arabia.

Hoda Elsayed Mohammed

Biology Department, Faculty of Sciences and Arts, Al Kamel Branch, University of Jeddah, Jeddah, Saudi Arabia.

*Author to whom correspondence should be addressed.


Abstract

Background: Anti-Inflammatory properties of turmeric and extra virgin olive oil have numerous health benefits. They exert and promote anti-inflammatory actions, moreover, each gives benefits that go beyond reducing inflammation.

Objective: The aim of our study is to evaluate and compare the immunomodulatory effect of each turmeric and extra virgin olive oil (EVOO) alone or in combination.

Methods: We demonstrated the serum level of pro-inflammatory cytokines IL-6 and IL-10 in healthy male Swiss albino mice (C57BL/6 strain) after oral intake of curcumin and extra virgin olive oil for six weeks by ELISA assay. 

Results: Our results showed that dietary intake of turmeric and EVOO had a reducing effect on serum IL-6 level and could increase the production of IL-10 level significantly. Inflammatory responses of turmeric and EVOO combination appear to be more effective on health by inhibition of IL 6 and induce IL 10 production. 

Conclusion: Anti-inflammatory effect of turmeric and EVOO can play an important role in modulating the level of IL 6 and IL-10. Moreover, co-administration of them having a greater anti-inflammatory effect. 

Keywords: Turmeric, extra-virgin olive oil, pro-inflammatory, anti-inflammatory, IL-6, IL-10, cytokines


How to Cite

Attiyah, S. M. and Mohammed, H. E. (2021) “Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice”, Journal of Pharmaceutical Research International, 33(39A), pp. 9–16. doi: 10.9734/jpri/2021/v33i39A32134.

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