Evolving Trends and Changing Perspectives in ANCA Associated Vasculitis– A Review
Monali Rajendrakumar Sahu *
Consultant Nephrology, Midas Multispeciality Hospital, Nagpur, Maharashtra, India.
Tanvi Dilip Wairagade
Consultant Nephrology, Midas Multispeciality Hospital, Nagpur, Maharashtra, India.
Sonali Dilip Wairagade
Department of Kayachikitsa, Datta Meghe Ayurved Medical College Hospital and Research Centre, Wanadongri, Nagpur, Maharashtra, India.
Ranjit S. Ambad
Department of Biochemistry, Datta Meghe Medical College, Shalinitai Meghe Hospital & Research Centre Wanadongri, Hingana, Nagpur-441110, Maharashtra, India.
Dhruba Hari Chandi
Department of Microbiology Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe), Wardha, India.
*Author to whom correspondence should be addressed.
Abstract
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a group of conditions characterized by inflammation and destruction affecting small to medium vessels accompanied by excess morbidity and mortality. These diseases present as multisystem diseases with variety of signs and symptoms. Earlier AAV were considered fatal diseases, however recent advances have changed them to chronic illnesses associated with morbidity& relapses. This review analyses recent developments in the pathogenesis, treatment and follow up of ANCA associated vasculitis.
Keywords: Anti-neutrophil cytoplasmic antibody (ANCA), Vasculitis, Microscopic polyangiitis (MPA), Granulomatosis with polyangiitis (GPA)