Microsponge: A Novel Tool for Topical Drug Delivery of Anti Rheumatoid Drugs
Dipti Gohil *
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
Krupa Patel
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
Kruti Patel
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
Shivani Tiwari
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
Priyank Patel
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
Nirmal Shah
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
*Author to whom correspondence should be addressed.
Abstract
Microsponge is developing field of technology which can achieve goal of site specific as well as controlled drug delivery. Physicochemical properties of microsponge like Particle size, particle size distribution, porosity, surface morphology plays a major role in selection of type of dosage form and route of administration for delivery of drug. Microsponge is also emerged as novel tool for delivering of drug by topical route. Topical route is having added advantage of formulation flexibility, greater patient compliance, improved safety and efficacy of formulation and aesthetic properties. Rheumatoid Arthritis is immunomodulatory disease which requires long term treatment for management of disease. Available oral formulation may cause liver toxicity upon long term use. Topical route can be suitable alternate route for delivery of drug with enhanced stability of drug, reduced side effects, and reduced frequency of administration. Due to porous and spongy structure of Microsponge, it has the capacity to entrap large amount of dose and can modify drug release too.
Keywords: Microsponge, topical drug delivery, rheumatoid arthritis, method of preparation, characterization