Journal of Pharmaceutical Research International

The mixed ligand lanthanum complexes have been synthesized using polydentate ligands. The (2Z)-2-(N-hydroxyimino)-1,2-diphenylethan-1-ol (cupron) was used as a primary ligand and L-isolucine, L-threonine, L-lysine and L-glycine were used as secondary ligands for the synthesis. Conductometry, elemental analysis, magnetic susceptibility measurements, complexometric estimation, UV-Visible spectroscopy, FTIR spectroscopy, thermal analysis and XRD methods were used for structural interpretation of all synthesized complexes. All complexes were solid and white and slight yellow in colour. They are non-electrolytic and diamagnetic in nature, as confirmed by conductometric and magnetic susceptibility methods respectively. All the complexes were synthesized by combination of lanthanum metal ion, primary ligand and secondary ligands in 1:2:1 ratio which was confirmed by elemental analysis. During reaction between lanthanum ion, primary ligand and secondary ligands there was transition of electrons which was confirmed by UV-Visible spectroscopy. Identification of functional group in the complexes was carried out and confirmed by FTIR spectroscopy. The decomposition temperature and thermal behaviour of the complexes have been concluded by thermal and XRD techniques. Tube dilution and agar cup methods have been employed to study antibacterial activities of all synthesized lanthanum complexes. The inhibition potential was seen to some extent.