Glutathione-S-Transferase Pi and Malondialdehyde in Alcoholic Patients Attending Smhrc and Avbrh Hospital
Ranjit S. Ambad
Department of Biochemistry Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur (Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha), India.
Suryakant Nagtilak *
Department of Biochemistry NAMO Medical Education and Research Institute Silvassa DNH, India.
Gangaram Bhadarge
Department of Biochemistry Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India.
Meghali Kaple
Department of Biochemistry Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Alcohol abuse is a global health problem. The liver maintains high muscle damage by over drinking because it is a major source of ethanol metabolism. Among substance abusers, about 35 % develop advanced liver disease because the number of viral mutations increases, slows down, or inhibits the progression of liver disease. Glutathione-S-transferase is a family of Phase II enzyme-releasing toxins that cause the synthesis of glutathione in a variety of chronic and external electrophilic types. GSTs are divided into two very different family members: family members bound by microsomal membrane and cytosolic.
Aim: To study the Glutathione S Transferase π and Malondialdehyde in Alcoholic Patients.
Materials and Methods: Present study comprises 100 Subjects were included in the study and distributed in two groups. Patients from group one was alcoholic patients, enrolled from medicine ward and 50 non-alcoholic healthy individuals from group two were from non-alcoholic population as well as medicine ward.
Results: Rise of GGT, AST and ALT in Alcoholic patients (54.54 ± 3.72, 19.21 ± 0.68 and 24.32 ± 1.27 respectively) as compare to healthy individuals (24.40 ± 3.16, 10.36±0.35 and 17.06±0.84 respectively). The level of GST-π was decreased in alcoholic patients (62.44±26.30) as compare to control group (83.26±32.71). Similarly, the level of MDA was raised in alcoholic patients (5.36 ± 0.51) as compare to healthy individuals (4.73 ± 0.21).
Conclusion: Present study suggests that it would be vital to contain SGOT, SGPT, GGT, MDA and GST-π calculation in the prognostic assessment of alcoholic patients.
Keywords: GST-π, Malondialdehyde, Alcohol abuse, SGOT, SGPT