Design, Formulation, and Physicochemical Evaluation of Occimum sanctum Containing Honey Based Hydrogel
Akhilesh Shewale *
Department of Periodontics, Swargiya Dadasaheb Kalmegh Smruti Dental College, Hingna, Nagpur, India.
Sneha Puri
Department of Periodontics, Swargiya Dadasaheb Kalmegh Smruti Dental College, Hingna, Nagpur, India.
Rashmi Bele
Department of Periodontics, Swargiya Dadasaheb Kalmegh Smruti Dental College, Hingna, Nagpur, India.
Mahvash Fatema
Department of Periodontics, Swargiya Dadasaheb Kalmegh Smruti Dental College, Hingna, Nagpur, India.
*Author to whom correspondence should be addressed.
Abstract
Background and Aim: The present study aims to formulate a hydrogel containing Tulsi (O. sanctum) and honey, to obtain a pharmaceutical topical preparation having desirable healing effects and antibacterial properties of both the ingredients.
Material and Method: Topical honey hydrogel formulation were prepared using 75%honey and 10% Occimum sanctum (Tulsi) with polymer carbopol 934. The prepared formulation was assessed for its pH, spreadability, swelling index and in-vitro release
Result: The pH and spreadability were in the range of 4.74 ± 0.02 and 7.75 ± 0.04 cm respectively. Carbopol based Honey –Tulsi Formulation showed a concentration-dependent increase in the amount of honey and O. sanctum diffused through dialysis method.
Conclusion: Within the limitations of the study, the results of our present study suggest that the studied Honey –Tulsi based hydrogel could be an economic indigenous substitute which is non-toxic, natural and efficient for clinical application.
Keywords: Honey, Ocimum sanctum, hydrogel