Levothyroxine Administration Timing in Hypothyroidism Patients
Mohammed Saleh Daher Albalawi *
Internal Medicine and Endocrinology Consultant King Salman Armed Forced Hospital, Tabuk, Saudi Arabia.
Shoog Mohsen R. Alharbi
University of Tabuk, Saudi Arabia.
Reem Hammad M. Albalawi
University of Tabuk, Saudi Arabia.
Khaled Abdullah S. Alasmari
University of Tabuk, Saudi Arabia.
Nada Sulaiman E. Alatawi
University of Tabuk, Saudi Arabia.
Thamer Awad Alatwi
University of Tabuk, Saudi Arabia.
Marwan Fahad H. Altemani
Internal Medicine Resident, King Salman armed forced hospital, Tabuk, saudi Arabia.
Lina Saleh S. Alahmadi
Internal Medicine Resident, AlNoor specialist Hospital, Makkah, Saudi Arabia.
Abeer Abdulrhman Basmih
Internal Medicine Resident, King Salman armed forced hospital, Tabuk, saudi Arabia.
Asmaa Ali Z. Sayis
Internal Medicine Resident, AlNoor specialist Hospital, Makkah, Saudi Arabia.
Doaa Mohammad S. Filmban
Internal Medicine Resident, AlNoor specialist Hospital, Makkah, Saudi Arabia.
Ahmed Abdullah Y. Alzahrani
Internal Medicine Resident, King Abdulaziz university Hospital,Jeddah, Saudi Arabia.
*Author to whom correspondence should be addressed.
Abstract
Levothyroxine is a synthetic T4 hormone that is biochemically and physiologically identical to the natural hormone, and it is used when the body is deficient in the natural hormone. This study was conducted to summarize the current evidence that compare evidence supporting morning dose to evening dose of levothyroxine in patients with hypothyroidism. A simple systematic review was carried out, searching databases PubMed, Google Scholar, and EBSCO. The authors extracted the needed data. There is conflicting data regarding effectiveness of morning dose versus evening dose in management of levothyroxine. More studies reported effectiveness of bedtime dose more than breakfast dose in hypothyroidism management. Numerous studies reported effectiveness of bedtime dose more than breakfast dose in hypothyroidism management. The most resent evidences recommended that, if possible, L‐T4 be consistently taken either 60 minutes before breakfast or at bedtime (3 or more hours after the evening meal), for optimal, consistent absorption.
Keywords: levothyroxine, hypothyroidism, dose timing