Prevalence of Urinary Tract Infection and Drug Resistance among Infants and Children in Pakistan
Muhammad Sohail
Department of Urology, Lahore General Hospital, Pakistan.
Maisam Ali Shahid
Department of Urology, Lahore General Hospital, Pakistan.
Kumail Sajjad *
Department of Urology, Lahore General Hospital, Pakistan.
Muhammad Ayub
Department of Urology, Lahore General Hospital, Pakistan.
Qasir Akram
Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Sobia Alyas
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.
Yousma Javed
Department of Dentistry, Combined Military Hospital, Lahore, Pakistan.
Muhammad Asim Rana
Department of Internal and Critical Care Medicine, Bahria International Hospital, Pakistan.
Qurban Ali
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.
Muhammad Mansoor Hafeez
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan and Department of Medicine Expert Doctor Private limited, Lahore Pakistan.
*Author to whom correspondence should be addressed.
Abstract
In infancy most common and a serious disease is known as Urinary tract infection (UTI). The aim of the current study is to evaluate the frequency and antibiotic resistant among infant presenting with UTI in Lahore General hospital, Lahore-Pakistan. The current observational study comprised 100 (n=100) cases diagnosed with UTI. The study was conducted at Lahore General Hospital, Pakistan, between March 2019 and January 2020. Data were collected and recorded on specified proformas that had information on demographics, biochemical analysis, and complaints, as well as the antibiotic used and blood cultures. The most common gram-negative bacilli (GNB) causing UTI was E. coli constitute about 72% followed by Klebsiella (11%), Enterobacter (7%) and Enterococcus (4%). Most of the isolated pathogens are highly resistant to ampicillin, cotrimoxazole, and cephalexin (72%–95%), have intermediate sensitivity to third- generation cephalosporins, and high sensitivity to amikacin, nitrofurantoin and ciprofloxacin. Similarly, the other pathogens showed different degree of occurrence and resistance against empirically used antibiotics. The most prevalent UTI causative organism among children was E. coli. The insulated microorganisms were highly resistant to ampicillin, and highly sensitive to amikacin.
Keywords: Antibiotic, Escherichia coli, resistance, sensitivity, UTI