Enhancement of Solubility and Dissolution Rate of BCS Class-II Fluvoxamine Tablets using Solvent Evaporation Solid Dispersion Technique
Martha Srinivas
*
Department of Pharmaceutics, Bhagwant University, Ajmer, Rajasthan, 305004, India and Department of Pharmaceutics, Joginpally B R Pharmacy College, Moinabad. Hyderabad, 500075, India.
Anoop Singh
Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajasthan, 305004, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: This research work was aimed to formulate Enhancing the solubility of Poorly soluble drug i.e. Fluvoxamine tablets by the solvent evaporation method, Fluvoxamine medicament is a selective serotonin reuptake inhibitor (SSRI) antidepressant agent.
Purpose: The BCS class II drug Fluvoxamine consist low aqueous solubility and low oral bioavailability, for this reason to improve the biological performance of Fluvoxamine drug by solid dispersion mechanism.
Methodolgy: The drug Fluvoxamine was formulated by using solvent evaporation technique, solid dispersions of Fluvoxamine were prepared with different carriers in different ratios of PEG 6000 & Mannitol (1:1, 1:2 and 1:3).
Results: Results of prepared solid dispersions of Fluvoxamine by solid dispersion method Finally by comparing all the formulations, formulation (SF3) containing Fluvoxamine and PEG 6000 (1:3) shows better results.
Conclusion: Here we concluded that the poorly soluble drug solubility improving by solvent evaporation solid dispersion mechanism, and also developed six Fluvovamine formulations (FDF1-FDF6) during this FDF4 shows maximum (98.9±0.8%) drug release at the end of time.
Keywords: Fluvoxamine, antidepressant, PEG 6000, mannitol, solvent evaporation, direct compression method