Evaluation of Catalase and Manganese in Type 2 Diabetic Patients in University of Port Harcourt Teaching Hospital
Arvin Nwakulite
Department of Medical Laboratory Science, Madonna University, Elele, Rivers State, Nigeria.
Emmanuel Ifeanyi Obeagu
*
Department of Medical Laboratory Science, Madonna University, Elele, Rivers State, Nigeria and Department of Medical Laboratory Science, Imo State University Owerri, Imo State, Nigeria.
Richard Eze
Department of Medical Laboratory Science, Madonna University, Elele, Rivers State, Nigeria.
C. C. N. Vincent
Department of Nursing Science, Imo State University, Owerri, Nigeria.
Ejike Felix Chukwurah
Department of Haematology and Immunology, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria.
Chukwuma J. Okafor
Department of Pathology and Biochemistry, State University of Zanzibar, Tanzania.
Adaobi Maryann Ibekwe
Department of Nursing Science, Nnamdi Azikiwe University,Nnewi Campus, Nnewi, Anambra State, Nigeria.
Calista Ndidi Adike
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Ufuoma Chukwuani
Department of Medical Laboratory Science, Igbinedion University Okada, Edo State, Nigeria.
Bart I. Ifionu
Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Ogun State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
This study was carried out to evaluate catalase and manganese in type 2 diabetes mellitus patients. A total of 40 subjects Were included in this study. This comprised of equal number of male and female subjects respectively. Enzyme linked immunosorbent assay (ELISA) method was used for this study. The result showed that there is a significant increase (P < 0.05) in the fasting blood sugar level of male diabetics (11.3±3.1) when compared with male non diabetics (4.0±0.4), and female diabetics (9.4±0.8) when compared with female non-diabetics (3.8±0.3). There is no significant increase (P<0.05) in the mean catalase value of male diabetics (77.3±137.7) when compared with male (256.3±207.6) and female non diabetics (225.1±233.9) But there is significant increase in female diabetics (27.8±14.7) when compared with controls (77.3±137.7) and female non diabetics (225.1±233.9).There is also significant decrease (P<0.05) in the mean Manganese value of male diabetics (0.5±0.6) when compared with male non diabetics (0.9±0.3) and female diabetic(0.2±0.1) when compared with female non-diabetics (0.3±0.1).The result shows that serum catalase level and manganese is decreased in diabetic patients. It is therefore suggested that type 2 diabetes patient should consume meals and supplement rich in catalase and manganese.
Keywords: Catalase, manganese, type 2 diabetic patients