Hepatoprotective Activity of Acampe praemorsa
Praveen Kumar Uppala
*
K. L. College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
G. S. N. Koteswara Rao
K. L. College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
A. Rajasekhar Reddy
K. L. College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
K. Umasankar
K. L. College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
C. Joshitha
Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
Kanagala Anusha
K. L. Business School, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
Nadeem Siddiqui
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
Sarada Prasanna Mallick
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, 522502, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Liver is one of major functional organ in body, its damage can alter body metabolisms and other organs’ function. So, it is very important to maintain the healthy liver. Now a days, different chemicals and inadequate use of medicines are causing liver impairments including alcohol consumption. There is a need to identify safe hepatoprotective drugs against liver diseases from different natural resources including medicinal plants. Several medicinal plants have been using in traditional medicines against several diseases including liver disease and many of them are not scientifically proven. So, the current study was aimed to evaluate hepatoprotective nature of Acampe praemorsa.
Methodology: The hepatoprotective activity of A. praemorsa was carried on ethanol-induced liver toxicity on albino wistar rats by evaluating the levels of liver biomarker enzymes such as aspartate aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Total protein (T.ptn), and Total bilirubin (T.Bil).
Results: The extracts of Acampe praemorsa were found to be safe at different doses as there were no mortality and physio-psychological changes observed in toxicity study. The extracts of Acampe praemorsa has showed dose dependent hepatoprotective activity on controlling the altered liver biomarker enzymes when compared along with standard drug Liv 52. The hydroalcoholic extract showed better activity compared to ethyl acetate extracts. The percentage protection on liver biomarker enzymes levels of hydro-alcoholic extract at 100, 200, and 400 mg/kg on AST, ALT, ALP, T.ptn, and T.Bil was found to be 62.72%, 60.06%, 61.77%, 63.96% and 58.58% respectively.
Conclusion: The results of recent study support traditional medicinal use of Acampe praemorsa and provides the information about its’ hepatoprotective nature. The hepatoprotective activity of A. praemorsa was definitely due to presence of different phytochemical compounds in it as it was compared with Liv 52 which was also an herbal drug.
Keywords: Liver, damage, ethanol, hepatoprotective, Acampe praemorsa, Liv 52