Androgenetic Alopecia as a Marker of Metabolic Syndrome
Faryal Hussain Memon
Department of Dermatology Liaquat, University Hospital Hyderabad, Jamshoro, Pakistan.
Abdul Ghani Rahimoon
Department of Medicine, LUMHS Jamshoro, Pakistan.
Pardeep Kumar
Social Security Hospital Hyderabad, Pakistan.
Shahid Hussain Memon
Department of Cardiology, LUMHS Jamshoro, Pakistan.
Erum Siddiqui
Department of Dermatology, Abbasi Shaheed Hospital, Karachi, Pakistan.
Tarachand Devrajani
Department of Medicine, LUMHS Jamshoro, Pakistan.
Samar Raza
Department of Medicine, LUH, Hyderabad, Jamshoro, Pakistan.
Syed Zulfiquar Ali Shah *
Department of Medicine, LUMHS Jamshoro, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Background: Alopecia induced by androgens in genetically predisposed individuals is termed as Androgenetic alopecia (AGA). There is proof appearance the relationship between Androgenetic alopecia and metabolic condition.
Objective: To determine frequency of metabolic syndrome in Androgenetic alopecia as a biomarker of disease in adult male patients.
Materials and methods: It was a Cross Sectional Study conducted at the Department of Dermatology, Liaquat University of Medical and Health Sciences Hospital, Jamshoro/Hyderabad.
Total 178 diagnosed male patients of Androgenetic alopecia were included. The grading of male pattern Androgenetic alopecia was done according to modified Norwood-Hamilton classification. Norwood-Hamilton Stage I-III were regarded to be mild to moderate and Stage IV and higher were regarded as severe. Vein was engorged by a tourniquet applied above the cubital fossa. Blood glucose levels were estimated. The level of triglycerides was determined. HDL-Cholesterol was estimated by a precipitant method. Descriptive statistics were calculated using SPSS. Chi square tests were applied to determine the relationship of independent variables with metabolic syndrome.
Results: The overall mean age of the patients was 39.08±10.14 years. The mean waist circumference, triglycerides, high-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose were 94.71±12.30 cm, 133.83±13.27 mg/dl, 48.10±7.89 mg/dl,102.94±17.67 mmHg, 76.88±8.56 mmHg, and 93.06±9.78 mg/dl respectively. A total of 10.1% of the patients were found to have metabolic syndrome. There was a significant association between metabolic syndrome and age and family income.
Conclusion: Metabolic syndrome was observed in 10.1% of the patients and this was more commonly found in: the age group >40 years, married individuals, low socioeconomic status individuals, and illiterate individuals.
Keywords: Metabolic syndrome, androgenetic alopecia, biomarker, male patients