Comparative Analysis of Adverse Drug Reactions between Interferon Alpha 2B and Sofosbuvir in the Treatment of Hepatits C at GIMHS, Sindh, Pakistan
Sajid Ali
Department of Pharmacy, Shah Abdul Latif University (SALU), Khairpur, Sindh, Pakistan.
Marvi Metlo
Department of Pharmacy, Shah Abdul Latif University (SALU), Khairpur, Sindh, Pakistan.
Zuheeb Ahmed
Department of Pharmacy, Shah Abdul Latif University (SALU), Khairpur, Sindh, Pakistan.
Tahseen Ahmed
Institute of Pharmaceutical Sciences, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan.
Arslan Ahmer *
Institute of Pharmaceutical Sciences, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan.
Muhammad Aslam Abbassi
Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan.
Saima Samtio
Department of Pharmacy, Shah Abdul Latif University (SALU), Khairpur, Sindh, Pakistan.
Syed Adeel Ahmed Shah
Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan.
Sham Lal
Institute of Microbiology, Shah Abdul Latif University (SALU), Khairpur, Sindh, Pakistan.
Rashid Ali Arbani
Department of Pharmacy, Shah Abdul Latif University (SALU), Khairpur, Sindh, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
A descriptive cross-sectional study was conducted on 300 patients selected by random sampling who were reported with Hepatitis-C at GIMHS. Questions were asked from patients regarding symptoms and adverse drug reactions (ADR’S). Results were analyzed by using SPSS-22. Out of total patients (n=300) the frequency of male gender was (n=192) as compared to females (n=108). Among 300 patients some patients were on sofosbuvir (n=150), patients on interferon (n=150). Rate of ADR’S observed with interferon as fever (n=28), anemia (n=27), hair loss (n=21), headache (n=19), insomnia (n= 11), nausea (n=13), depression (n=14, 09), malaise (n=25), vomiting (n=06), ulcer (n=13), pain and redness at site of injection (n=17). While rate of ADR’S in patients who were on sofosbuvir, fever (n=33), chill (n=17), nausea (n=28), anemia (n=06), headache (n=14), insomnia (n=13), loss of appetite (n=5), diarrhea (n=1). This study concluded that as compared to Interferon, rate of ADR’S were less with Sofosbuvir.
Keywords: Hepatitis, interferon, sofosbuvir, compliance