Anti-Mycobacterium Metabolite from Marine Sponge Iricinia fusca
Srinu Meesala *
Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411008, India.
Ruby Singh
Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411008, India.
Milind G. Watve
Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411008, India.
*Author to whom correspondence should be addressed.
Abstract
Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of compounds were established by 1D and 2D NMR and MS data. Compound 1 exhibited strong antibacterial activity against Mycobacterium smegmatis at MIC 116 μM. Compounds 1-3 showed neither antifungal nor cytotoxic activity.
Keywords: Sponge, NMR and mass spectrometry, natural products, antimicrobial and anticancer activity.