Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach
Pavan Kumar Tummala
Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Sreeja Nannapaneni
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Sumana Pratyusha Durvasula
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Supriya Chadalavada
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Sunandini Venigandla
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Srikanth Vemuru
Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
Suryanarayana Veeravilli
Department of Humanities and Basic Sciences, Aditya Engineering College, Surampalem, Andhra Pradesh, India.
Maheswara Reddy Mallu *
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Phytocompounds in medicinal plants have a wide range of properties and are alternative medicines for those who cannot be helped by conventional medicine.
Objective: In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts.
Methods: Gas chromatography and Mass spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area.
Results: The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer.
Conclusion: Out of twenty selected compounds, docking results showedMethyl-1-Cyclohexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.
Keywords: Hemidesmus indicus, anti-diabetic, anticancer, docking studies, alpha glucosidase