Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review
Viviane Ferraz Ferreira de Aguiar
Federal University of Pará (UFPA), Belém, Pará, Brazil.
Dayara de Nazaré Rosa de Carvalho *
State University of Pará (UEPA), Belém, Pará, Brazil.
Dandara de Fátima Ribeiro Bendelaque
Federal University of Pará (UFPA), Belém, Pará, Brazil.
Lorena Nayara Alves Neves
Metropolitan University Center of the Amazon (UNIFAMAZ), Belém, Pará, Brazil.
Celice Ruanda Oliveira Sobrinho
Metropolitan University Center of the Amazon (UNIFAMAZ), Belém, Pará, Brazil.
Paula Sousa da Silva Rocha
Federal University of Pará (UFPA), Belém, Pará, Brazil.
Rafael Everton Assunção Ribeiro da Costa
University State of Piauí (UESPI), Teresina, Piauí, Brazil.
Cidianna Emanuelly Melo do Nascimento
University State of Ceará (UECE), Fortaleza, Ceará, Brazil.
Susi dos Santos Barreto de Souza
Federal University of Pará (UFPA), Belém, Pará, Brazil.
Marcela Raissa Asevedo Dergan
State University of Pará (UEPA), Belém, Pará, Brazil.
Mioni Thieli Figueiredo Magalhães Brito
Federal University of Pará (UFPA), Belém, Pará, Brazil.
Juarez Antônio Simões Quaresma
Federal University of Pará (UFPA), Belém, Pará, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Objective: To analyze the toxicological effects of anti-tuberculosis chemotherapy in adults in national and international literature in the period from 2015 to 2020.
Methodology: It is a qualitative descriptive research, of the type Integrative Literature Review (ILR). In the VHL databases PubMed / Medline, Arca, Web of Science, Microsoft Academic and Cochrane Library. Data analysis was performed with the aid of the IRaMuTeQ software.
Results: 36 articles were found in which the following categories were created: 1) Association of hepatotoxicity and appearance of liver damage; 2) The incidence of adverse events related to antituberculin therapy; 3) Risk factors of regular consumption of antituberculins; 4) Intensive renal treatment for patients with nephrotoxicity.
Conclusion: in our review we identified that the elderly, HIV positive and alcohol users are more likely to have toxicological effects during treatment, which can lead to a possible abandonment of treatment.
Keywords: Toxicity, antitubercular agents, drug therapy, adult