Synthesis, Characterization and Evaluation of Anti-tubercular Activity of Ofloxacin Chalcone Conjugates
Ramakrishna Chintakunta
*
JNTUA Anantapuramu-515001, Andhra Pradesh, India.
Venkata Subbareddy Gopireddy
Department of Chemistry, JNTUA college of engineering, Pulivendula-516390, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Synthesis and characterization of Ofloxacin Chalcone derivatives were carried out and evaluated for their antitubercular activity. Synthesized Ofloxacin Chalcone derivatives (Compound A to F). These molecules are characterized by analytical methods (TLC), melting point, and Spectroscopic methods (FT-IR, Mass, NMR). The evaluated antitubercular activity of molecules of synthesized compounds and Ciprofloxacin Pyrazinamide, and Streptomycin as standard drugs. concentrations of synthesized derivatives were prepared (0.8, 1.6, 3.12, 6.25, 12.5, 25, 50, 100 µg/ml) by using sterile deionized water as a solvent. Antitubercular Assay was Performed by Mycobacterium tuberculosis using the MABA method. Analyzed MIC values. Compound E showed the best results among 6 Compounds at a very low concentration at 3.12 µg/ml.
Keywords: Ofloxacin chalcone conjugate, anti-tubercular activity, blanc reaction.