Evaluation of Some Biochemical Parameters of Wistar Rats Induced by Staphylococcus aureus Isolated from Pneumonia Patients
Felix Oghenemaro Enwa *
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, Delta State University, PMB 1, Abraka, Nigeria.
Johnson Daniel Jemikalajah
Department of Microbiology, Faculty of Pharmacy, Delta State University, Abraka, Nigeria.
Collins Ohwonigho Adjekuko
Department of Medical Laboratory Services, General Hospital Okwe, Delta State, Nigeria.
Clever Blessing Ogbare
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, Delta State University, PMB 1, Abraka, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
The effect and extent of changes in some biochemical parameters associated with pneumonia caused by Staphylococcus aureus were investigated in serum samples of Wistar rats. 0ne thousand five serum samples were collected randomly. The serum samples were tested for sodium, potassium, urea, creatinine and chloride by colorimetric methods. The concentrations of sodium ranged from 133.6±4.615 to 143.8±6.906, potassium values ranged from 5.78±1.26 to 8.02±0.779, urea gave a range of 10.143±0.69 to 14.444±2.404, chloride values ranged from 94.8±2.683 to 104.142±8.49, while creatinine values ranged from 0.489±0.033 to 1.7±2.404. The results indicated that Staphylococcus aureus has a significant effect on the electrolyte balance causing hyperkalemia and hyponatremia when compared to normal blood value. It had a remarkable effect on creatinine level with only slight effect on urea. There is need to monitor the electrolyte levels in Staphylococcus aureus infection since alteration in the electrolyte levels could be harmful to health.
Keywords: Biochemical parameters, Staphylococcus aureus, wistar rats, pneumonia patients