Mouth Dissolving Tablets of Favipiravir using Superdisintegrants: Preparation, Optimization and In-vitro Evaluation
D. Avinash *
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences (Autonomous), Lam, Guntur-522034, Andhra Pradesh, India.
Madhu Gudipati
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences (Autonomous), Lam, Guntur-522034, Andhra Pradesh, India.
M. V. Ramana
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences (Autonomous), Lam, Guntur-522034, Andhra Pradesh, India.
Pallavi Vadlamudi
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences (Autonomous), Lam, Guntur-522034, Andhra Pradesh, India.
Rama Rao Nadendla
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences (Autonomous), Lam, Guntur-522034, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
To formulate and evaluate the mouth dissolving tablet dosage forms of favipiravir using various superdisintegrants by using wet granulation technique.
Batches of favipiravir Mouth dissolving tablets were formulated by using the wet granulation technique. The formulated granules were evaluated for their flow properties as a pre-compression parameter and the friability, hardness, disintegration, wetting ratio, wetting time, dissolution, and drug release parameters were evaluated as post-compression parameters. The effect of the varying concentrations of superdisintegrants on the formulation for disintegration time was ascertained and the results were compared.
The tablet had friability and hardness values ranging from 0.60 to 0.68 % and 3.9 to 4.3 (kg/cm2). Tablet weights did not vary significantly but the disintegration time varied from 44.66 to 142.66±2.51 min and the wetting time varied from 45.33 to 144 min and the optimal batch of tablets shows a drug release of 98.8% within 60 min and first-order release kinetics of the formulations are compared.
Keywords: Favipiravir, super disintegrants, crospovidone, croscarmellose sodium, sodium starch glycolate, wetting time, wetting ratio, disintegration time.