Synthesis, Characterization and Preliminary Biological Evaluation of New 3 and 4-nitro Isoindoline-1, 3-dione/phthalimide Analogues
Sharad Sankhe
Organic Research Laboratory, Patkar-Varde College of Science, Goregaon (West), Mumbai 400 062, India.
Nitesh Chindarkar *
Organic Research Laboratory, Patkar-Varde College of Science, Goregaon (West), Mumbai 400 062, India.
*Author to whom correspondence should be addressed.
Abstract
Aims: To synthesize new nitroisoindoline-1,3-diones analogues and evaluate their preliminary biological activities
Methodology: New isoindoline-1,3-diones analogues were synthesized by coupling phthalic anhydride derivatives with appropriate aromatic amines. Newly synthesized heterocyclic compounds were evaluated for their in vitro antibacterial activity against gram-positive bacterial strains and gram-negative bacterial strains. They were also tested for their in vitro antifungal activity against fungi strains. Determination of the preliminary antibacterial and antifungal activity were investigated using agar-dilution method. The structures of newly synthesized analogues were elucidated by 1H and 13C-NMR techniques.
Results: Bioassay indicated that some of the newly synthesized isoindoline-1,3-dione analogues shows moderate biological activities.
Conclusion: Newly synthesized analogues can be used as antibacterial or antifungal agents on modifications.
Keywords: Biological activity, isoindoline-1,3-dione/phthalimide analogues, 3-nitro and 4-nitro phthalic anhydride, Primary aromatic amine.