In-vivo Hypoglycemic Activity of Grewia asiatica Fruit Extract in Streptozotocin Mediated Diabetic Rats

Zuneera Akram *

Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.

Aisha Noreen

Department of Pharmaceutical Chemistry, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.

Muzammil Hussain

Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.

Maryam Inayat

Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.

Sobia Akhter

Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.

Usman Ghani Farooqi

Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.

Anum Akram

Indus Hospital, Karachi, Pakistan.

Waqar Ahmed Sabzoi

Department of Pharmaceutics, Faculty of Pharmacy, University of Sindh, Jamshoro, Sindh, Pakistan.

*Author to whom correspondence should be addressed.


Abstract

Diabetes mellitus has high global prevalence and occurrence and is considered to bean endocrinological and/or metabolic disorder. Conventional drug treatment is costly and has toxic side effects, although it is successful in treating diabetes mellitus. If effective and less toxic, herbal medicine will thus include alternative therapy. This research has been designed to investigate the role of Grewia asiatica extract in the control of diabetes in male albino rats with Streptozotocin mediated type 2 diabetes. Grewia asiatica fruit extract at a dose of 200mg/kg was given to Streptozotocin mediated type II DM Rats. A known anti-diabetic drug, Glibenclamide has been used as a standard drug. The method of the research was to monitor the effect of Grewia asiatica on the blood glucose level of Rats. In this study, Rats were split into four categories i.e. Control, Streptozotocin treated, Streptozotocin + Glibenclamide treated and Streptozotocin +Grewia asiatica extract-treated group.  Grewia asiatica fruit extract significantly improve the blood glucose levels as compared to the standard drug Glibenclamide in Streptozotocin mediated diabetic group.

Conclusion: It was concluded that Grewia asiatica may be used in the treatment of diabetes or decreasing the elevated level of blood sugar.

Keywords: Streptozotocin, diabetes mellitus, glibenclamide, Grewia asiatica.


How to Cite

Akram, Z., Noreen, A., Hussain, M., Inayat, M., Akhter, S., Farooqi, U. G., Akram, A. and Sabzoi, W. A. (2021) “In-vivo Hypoglycemic Activity of Grewia asiatica Fruit Extract in Streptozotocin Mediated Diabetic Rats”, Journal of Pharmaceutical Research International, 33(1), pp. 68–75. doi: 10.9734/jpri/2021/v33i131140.

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