Bio-Fabrication of ZnO-CuO Nanoporous Composite and Its Application as Nanolarvicidal Agent for Malaria Vectors

Zaccheus Shehu; Ezra Abba; Danbature Wilson Lamayi; Kennedy Poloma Yoriyo; Zainab Adamu Abubakar; Zungi Namau Kenneth; Zirmba Usiju; Amina Abubakar

doi:10.9734/jpri/2020/v32i3430962

Bio-Fabrication of ZnO-CuO Nanoporous Composite and Its Application as Nanolarvicidal Agent for Malaria Vectors

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Published: 2020-12-10

DOI: 10.9734/jpri/2020/v32i3430962

Page: 31-39

Issue: 2020 - Volume 32 [Issue 34]

Zaccheus Shehu *

Department of Chemistry, Faculty of Science, Gombe State University, Nigeria.

Ezra Abba

Department of Zoology, Faculty of Science, Gombe State University, Nigeria.

Danbature Wilson Lamayi

Department of Chemistry, Faculty of Science, Gombe State University, Nigeria.

Kennedy Poloma Yoriyo

2Department of Zoology, Faculty of Science, Gombe State University, Nigeria.

Zainab Adamu Abubakar

Department of Biology, Faculty of Science, Gombe State University, Nigeria.

Zungi Namau Kenneth

Department of Zoology, Faculty of Science, Gombe State University, Nigeria.

Zirmba Usiju

Department of Zoology, Faculty of Science, Gombe State University, Nigeria.

Amina Abubakar

Department of Biology, Faculty of Science, Gombe State University, Nigeria.

*Author to whom correspondence should be addressed.

Abstract

Bio-fabrication of ZnO-CuO nanoporous composite was successfully synthesized using Gum Arabic. The morphology, elemental composition, surface plasmon resonance and functional groups bonds of the ZnO-CuO nanoporous composite were confirmed by SEM, EDX, UV-Visible and FTIR techniques respectively. Nanolarvicidal activity of ZnO-CuO nanoporous composite was tested against 1^st, 2^nd, 3^rd, and 4^th instars of malaria vectors for 24 hours using different concentrations. The lethal concentrations (LC₅₀) of ZnO-CuO nanoporous composite against 1^st, 2^nd, 3^rd, and 4^th instars were found to be 8.841, 8.734, 8.963 and 10.557 mg/L respectively. Whereas, the LC₉₀ of ZnO-CuO nanoporous composite against 1^st, 2^nd, 3^rd, and 4^th instars were found to be 19.062, 28.063, 40.888 and 79.567 mg/L respectively. For all instars, the correlation coefficients were found in the range of 0.945 to 0.999 and it indicates concentration dependent larvicidal activity. It was observed that the lower the instar, the higher the larvicidal activity and conversely. Therefore, ZnO-CuO nanoporous composite could be used as nanolarvicidal agent especially for malaria vectors.

Keywords: Bio-fabrication, ZnO-CuO nanoporous composite, nanolarvicidal, malaria Vector, gum arabic

How to Cite

Shehu, Z., Abba, E., Lamayi, D. W., Yoriyo, K. P., Abubakar, Z. A., Kenneth, Z. N., Usiju, Z. and Abubakar, A. (2020) “Bio-Fabrication of ZnO-CuO Nanoporous Composite and Its Application as Nanolarvicidal Agent for Malaria Vectors”, Journal of Pharmaceutical Research International, 32(34), pp. 31–39. doi: 10.9734/jpri/2020/v32i3430962.