In vitro Anticancer and Antimicrobial Proprieties of Carica papaya against Biochemically Characterized Clinical and Standard Microbes
Nureen Zahra
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Farheen Ansari
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Sumaira Shaheen
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Gulshan Parveen
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Rabia Rasool
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Modasrah Mazhar
Department of Eastern Medicine and Surgery Qarshi University Lahore, Pakistan.
Qaiser Akram
Department of Pathobiology KBCMA, CVAS Narrowal University of Veterny and Animal Science, Pakistan.
Muhammad Sajid Rasheed
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Qurban Ali
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Arif Mailk *
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
The bacterial pathogens have established various defense system against antimicrobial agents. The main mechanism of action of antibiotic resistance is obtained by pathogenic microorganisms, which directly involved in the diagnosis of various therapeutic plants with their significant antimicrobial properties. The current study investigated the antimicrobial and anticancer properties of Carica papaya. Fresh sample of C. papaya was collected in the native area of Punjab and selected isolate were tested against the aqueous, chloroform, ethanol, methanol extracts of C. papaya and anti-microbial activity by disc diffusion method. Anticancer activity was carried out in the HeLa cell line in above mention fractions of the extract at different concentration. The present study concluded, the extracts of the specific plants, particularly the ethanol and methanol extracts established the potential role against bacterial strain and HeLa cell line. It has also been concluded that these extracts might be implicated as natural products and serve to mediate as novel pharmaceuticals and therapeutic drugs.
Keywords: Carica papaya antifungal, anticancer, drugs, pathogens, hela cell lines