Endocrine Markers of Fertility Potential in Reproductive Age Women with Idiopathic Hyperprolactinemia
Alina Valerievna Atalyan *
FSBSI "Scientific Center of Family Health Problems and Human Reproduction", 664003, Irkutsk, St. Timiryazeva 16, Russia.
Leonid Fedorovich Shelokhov
FSBSI "Scientific Center of Family Health Problems and Human Reproduction", 664003, Irkutsk, St. Timiryazeva 16, Russia.
Lyubov Ilinichna Kolesnikova
FSBSI "Scientific Center of Family Health Problems and Human Reproduction", 664003, Irkutsk, St. Timiryazeva 16, Russia.
*Author to whom correspondence should be addressed.
Abstract
Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of reproductive age manifested with menstrual irregularity and sterility subfertility among the majority of women with this disorder.
Objective: The aim of this study was to assess the endocrinal markers of inferility in premenopausal women with idiopathic hyperprolactinemia.
Materials and Metahodology: The study included 82 women: 27 healthy women, 22 fertile women with idiopathic HP and 33 patients with endocrine sub fertility with idiopathic HP. All women underwent a standard history taking, clinical examinations. Lab tests were performed in all women and included the detection of the concentrations of prolactin, thyroid-stimulating hormone, thyroxine, triiodothyronine, cortisol, gonadotrophic hormones, testosterone, and estradiol by ELISA method.
Results: The study results demonstrated that subfertile women with HP are characterized by an increase of follicle-stimulating hormone and free triiodothyronine and a decrease of estradiol and cortisol when compared with fertile patients with HP and Healthy patients.
Conclusion: The better glucocorticoid and ovarian function of fertile women with HP supposed to be an essential issue in their reproductive ability.
Keywords: Prolactin, gonadotropins, thyroid-stimulating hormone, thyroid hormones, cortisol, sex steroids, idiopathic hyperprolactinemia, endocrine infertility.