Moringa oleifera Derived Phytochemicals against Shikimate Dehydrogenase of Helicobacter pylori Causing Peptic Ulcer
Sonali Suchismita Behera
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Seema Suvadarshini
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Truptimayee Chhotaray
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Archita Sahoo
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Subhadarshini Satapathy
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Manasi Mohapatra
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Bhagyeswari Behera
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Srimay Pradhan *
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Moringa oleifera plant extract is traditionally used to cure Peptic ulcer. It is caused by Helicobacter pylori. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 9-octadecenoic acid can effectively deactivate the shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.
Keywords: Phytochemical, Moringa oleifera, Helicobacter pylori, peptic ulcer.