Moringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid
Sonali Suchismita Behera
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Seema Suvadarshini
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Ipsita Aparajita Mohapatra
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Sonali Dash
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Akshaya Kumar Sahoo
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Soumyashree Nayak
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Meenakshee Mohanty
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Punya Prateek Majhi
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Srimay Pradhan *
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Phytochemicals from Moringa oleifera plant extract can cure Typhoid. It is caused by Salmonella typhi. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 4,8,12,16-tetramethylheptadecan-4-olide can effectively deactivate the 2-hydroxy-3-oxopropionate reductase enzyme thereby interrupting the life cycle of the organism.
Keywords: Phytochemical, Moringa oleifera, Salmonella typhi, typhoid.