The Effect of Creatine Supplementation with Resistance Training on the Levels of Renin and Aldosterone in Wistar Rats
Shadi Hamedi
Faculty of Physical Education and Sports Sciences, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran.
Gholam Reza Sharifi *
Faculty of Physical Education and Sports Sciences, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran.
Marzieh Kafeshani
Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
*Author to whom correspondence should be addressed.
Abstract
Objective: The aim of the present study was to compare the effect of creatine 2% and 5% supplementation with resistance training on the levels of renin and aldosterone
Methods: The 60 Wistar rats were randomly assigned to six groups (resistance training, creatine 2% and creatine 5%, resistance training plus creatine 2% supplementation, resistance training plus creatine 5% supplementation, control). The training included 8 weeks and 5 sessions a week climbing a 1-meter ladder with 26 rungs with 2-cm distances. The One – way analysis of variance (ANOVA) test was used for comparing the variables between groups and LSD test was used for pair-wise comparisons.
Results: There was no significant difference between mean differences of renin level in different groups compared to the control group. Butthere was a significant difference between mean difference of aldosterone level in creatine 5% groups and control group as well as between resistance training plus creatine 2% and creatine 5% groups (p < 0.05). Also, there was significant difference between mean difference of aldosterone level in resistance training and creatine 5% groups (p < 0.05).
Conclusion: As regard to result of the present study consumption of creatine 2% and 5% supplementation may be useful and safe for human so further studies is suggested.
Keywords: Creatine, resistance training, rennin, aldosterone