Michelia champaca L. Derived Phytochemicals against Peptidase Do of Bordetella pertussis Causing Cough
Sanjeeb Kumar Dash
Centurion University of Technology and Management, Odisha, India.
Sidhartha Ray
Centurion University of Technology and Management, Odisha, India.
Smruti Ranjan Behera
Centurion University of Technology and Management, Odisha, India.
Soumya Jal
Centurion University of Technology and Management, Odisha, India.
Dipankar Bhattacharyay *
Centurion University of Technology and Management, Odisha, India. and Go to Market Laboratory, Gram Tarang, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Phytochemicals from Michelia champaca L. plant extract are traditionally used to cure cough. Cough can be caused by many reasons. Caugh can be caused by the infection of Bordetella pertussis. The objective of the study is to identify the phytochemical of Michelia champaca capable of curing cough. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that magnoflorine can effectively deactivate the peptidase Do enzyme which will interrupt the life cycle of the microorganism and inhibit the multiplication.
Keywords: Phytochemical, Michelia champaca, Bordetella pertussis, cough