Budleja asiatica Derived Phytochemicals against Eye Disease
Sarthak Siddhant Mishra
Centurion University of Technology and Management, Odisha, India.
Sasmita Patra
Centurion University of Technology and Management, Odisha, India.
Bhakti Bhusan Das
Centurion University of Technology and Management, Odisha, India.
Dipankar Bhattacharyay
Centurion University of Technology and Management, Odisha, India.
Mukundjee Pandey *
Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
The secondary metabolites in the plants are the reason for curing various diseases. And the phytochemicals present in Budleja asiatica plant extract can cure Eye disease which is caused by Haemophilus influenzae is a facultatively anaerobic, gram-negative pathogenic bacteria. For analysis of ligand-protein interaction, the molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that lignoceric acid can effectively deactivate Aspararte semialdehyde dehydrogenase enzyme which is important macromolecule for the regulation of amino acid biosynthesis resulting in interrupting the life cycle of the microorganism.
Keywords: Phytochemical, lignoceric acid, Haemophilus influenzae