Eclipta alba Derived Phytochemicals against Jaundice
Sutapa Mohanty
Centurion University of Technology and Management, Odisha, India.
Mukesh Kumar Biswal
Centurion University of Technology and Management, Odisha, India.
Sanchayita Nayak
Centurion University of Technology and Management, Odisha, India.
Bhagyeswari Behera
Centurion University of Technology and Management, Odisha, India.
Ushasree Mandal
Centurion University of Technology and Management, Odisha, India.
Srimay Pradhan *
Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Phytochemicals otherwise known as secondary metabolites means the small organic molecules that are not essential for growth, development and reproduction but can protect from various diseases. Infact these phytochemicals are the key source of medicine. Secondary metabolites from Eclipta alba plant extract are traditionally used to cure Jaundice which is caused by Leptospira interrogans. The curative property of Eclipta alba against Leptospira interrogans was proved by molecular docking method in “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” recommended that pentadecan, heptadecane, 6,10,14-trimethyl-2-petadecanone can successfully deactivate the thioredoxin-disulfide reductase enzyme thereby disrupting the cellular function as well as the lifecycle of causative organism.
Keywords: Phytochemical, Eclipta alba, Leptospira interrogans, jaundice